![]() ![]() There were no differences in timing or extinction of conditioned responses between groups and conditioning deficits did not correlate with the degree of tremor or ataxia as rated by clinical scores. Impairment of eyeblink conditioning was not due to low-dose beta-blocker medication.Īdditionally, acquisition of conditioned eyeblink response was reduced in ET subjects regardless of the presence of cerebellar signs in clinical examination. The ability to acquire conditioned eyeblink responses was significantly reduced in ET subjects compared with controls. Seven ET subjects and three controls on low-dose beta-blocker treatments, which had no effect on eyeblink conditioning in animal studies, were allowed into the study. Care was taken to examine subjects without medication affecting central nervous functioning. Six ET subjects exhibited accompanying clinical signs of cerebellar dysfunction. Twenty-three ET subjects (13 males, 10 females mean age 44.3 ± 22.3 years, mean disease duration 17.4 ± 17.3 years) and 23 age-matched healthy controls were studied on two consecutive days using a standard delay eyeblink conditioning protocol. ![]() Conditioning of the eyeblink reflex is a well-established paradigm to assess motor learning. Evidence of motor learning deficits would strengthen the hypothesis of olivo-cerebellar involvement in ET. Besides motor coordination, the cerebellum is critically involved in motor learning. 5 One of the earlier tremor scales developed that is still in use today is the Fahn–Tolosa–Marin Tremor Rating Scale.Ībstract Several lines of evidence point to an involvement of the olivo-cerebellar system in the pathogenesis of essential tremor (ET), with clinical signs of cerebellar dysfunction being present in some subjects in the advanced stage. In an attempt to standardize the evaluation of tremor (particularly for clinical research purposes), a number of rating scales have been developed that optimize comparability between studies and patient populations. Sought to determine the change in tremor amplitude that corresponds to a 1-point change in a typical 5-point Tremor Rating Scale (TRS) commonly used in the clinical assessment of tremor. The second small study conducted in the U.S. ![]()
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